Drug interactions
Carvedilol + Ranolazine
Severity: Minor
Carvedilol and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits CYP2D6 and P-glycoprotein, which may increase carvedilol exposure modestly. Higher carvedilol levels can cause greater bradycardia and hypotension, though the combination is frequently used in angina without major issues.
What this interaction means in plain words
Carvedilol and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine weakly inhibits CYP2D6 and P-glycoprotein, reducing carvedilol clearance.
What to do
Monitor heart rate and blood pressure when starting ranolazine. Adjust the carvedilol dose if symptomatic bradycardia or hypotension appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Carvedilol with Ranolazine?
MediHelp rates the interaction as minor. Carvedilol and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine inhibits CYP2D6 and P-glycoprotein, which may increase carvedilol exposure modestly. Higher carvedilol levels can cause greater bradycardia and hypotension, though the combination is frequently used in angina without major issues.
How serious is the interaction between Carvedilol and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting ranolazine. Adjust the carvedilol dose if symptomatic bradycardia or hypotension appears.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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