Drug interactions
Carvedilol + Repotrectinib
Severity: Moderate
Carvedilol and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol inhibits P-glycoprotein and could modestly raise exposure to repotrectinib, which is a P-gp substrate. Higher repotrectinib levels may increase neurologic and other dose-related adverse effects.
What this interaction means in plain words
Carvedilol and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Repotrectinib belongs to Oncology.
Why it happens
Carvedilol inhibits intestinal P-glycoprotein efflux, potentially increasing repotrectinib absorption.
What to do
Monitor for repotrectinib adverse effects such as dizziness, ataxia and paresthesia when carvedilol is started or stopped. Reduce the repotrectinib dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Carvedilol with Repotrectinib?
MediHelp rates the interaction as moderate. Carvedilol and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol inhibits P-glycoprotein and could modestly raise exposure to repotrectinib, which is a P-gp substrate. Higher repotrectinib levels may increase neurologic and other dose-related adverse effects.
How serious is the interaction between Carvedilol and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for repotrectinib adverse effects such as dizziness, ataxia and paresthesia when carvedilol is started or stopped. Reduce the repotrectinib dose if toxicity appears.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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