Drug interactions
Armodafinil + Repotrectinib
Severity: Major
Armodafinil and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may decrease repotrectinib exposure by inducing CYP3A4. Reduced levels could compromise antitumor activity. Labeling advises avoiding moderate and strong CYP3A inducers.
What this interaction means in plain words
Armodafinil and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Armodafinil belongs to Central Nervous System; Repotrectinib belongs to Oncology.
Why it happens
CYP3A4 induction by armodafinil increases the metabolism of repotrectinib, a CYP3A4 substrate.
What to do
Avoid the combination and use a non-inducing alternative to armodafinil. If it is unavoidable, monitor for loss of tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Armodafinil
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Bosentan + Repotrectinib Major
- Carbamazepine + Repotrectinib Major
Frequently asked questions
Can I take Armodafinil with Repotrectinib?
MediHelp rates the interaction as major. Armodafinil and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Armodafinil may decrease repotrectinib exposure by inducing CYP3A4. Reduced levels could compromise antitumor activity. Labeling advises avoiding moderate and strong CYP3A inducers.
How serious is the interaction between Armodafinil and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative to armodafinil. If it is unavoidable, monitor for loss of tumor response.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
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