Drug interactions
Aprepitant + Repotrectinib
Severity: Major
Aprepitant and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is a CYP3A4 substrate, and aprepitant may raise its concentrations. This could worsen CNS effects such as dizziness and ataxia, as well as other toxicities.
What this interaction means in plain words
Aprepitant and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Repotrectinib belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, decreasing repotrectinib clearance.
What to do
Avoid the combination and choose an alternative antiemetic where possible. Monitor for neurologic and other adverse effects if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
- Carbamazepine + Repotrectinib Major
Frequently asked questions
Can I take Aprepitant with Repotrectinib?
MediHelp rates the interaction as major. Aprepitant and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib is a CYP3A4 substrate, and aprepitant may raise its concentrations. This could worsen CNS effects such as dizziness and ataxia, as well as other toxicities.
How serious is the interaction between Aprepitant and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiemetic where possible. Monitor for neurologic and other adverse effects if it cannot be avoided.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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