Drug interactions
Apalutamide + Repotrectinib
Severity: Contraindicated
Apalutamide and Repotrectinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide markedly lowers repotrectinib exposure, which may lead to loss of antitumor activity. Repotrectinib labeling contraindicates strong CYP3A inducers.
What this interaction means in plain words
Apalutamide and Repotrectinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Repotrectinib belongs to Oncology.
Why it happens
Strong induction of CYP3A4 (and P-gp) by apalutamide increases repotrectinib clearance.
What to do
Do not coadminister; choose an alternative to apalutamide or repotrectinib.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Repotrectinib
Frequently asked questions
Can I take Apalutamide with Repotrectinib?
MediHelp rates the interaction as contraindicated. Apalutamide and Repotrectinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide markedly lowers repotrectinib exposure, which may lead to loss of antitumor activity. Repotrectinib labeling contraindicates strong CYP3A inducers.
How serious is the interaction between Apalutamide and Repotrectinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose an alternative to apalutamide or repotrectinib.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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