Drug interactions
Bosentan + Repotrectinib
Severity: Major
Bosentan and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce repotrectinib plasma concentrations through CYP3A4 induction. Lower exposure may reduce antitumor efficacy.
What this interaction means in plain words
Bosentan and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Repotrectinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, accelerating repotrectinib metabolism.
What to do
Avoid concomitant use because repotrectinib labeling advises against moderate and strong CYP3A inducers. Consider an alternative to bosentan, such as another pulmonary hypertension agent, if appropriate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Carbamazepine + Repotrectinib Major
Frequently asked questions
Can I take Bosentan with Repotrectinib?
MediHelp rates the interaction as major. Bosentan and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan may reduce repotrectinib plasma concentrations through CYP3A4 induction. Lower exposure may reduce antitumor efficacy.
How serious is the interaction between Bosentan and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use because repotrectinib labeling advises against moderate and strong CYP3A inducers. Consider an alternative to bosentan, such as another pulmonary hypertension agent, if appropriate.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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