Drug interactions
Carvedilol + Sevoflurane
Severity: Moderate
Carvedilol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane causes vasodilation and myocardial depression, and carvedilol adds beta-blockade and alpha-1 blockade. Together they can cause marked hypotension and bradycardia during anesthesia.
What this interaction means in plain words
Carvedilol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: volatile anesthetic vasodilation and negative inotropy plus beta and alpha-1 adrenergic blockade.
What to do
Generally continue beta-blockers perioperatively, and make the anesthesia team aware of carvedilol use. Monitor blood pressure and heart rate continuously and treat hypotension with fluids or vasopressors as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Sevoflurane
Frequently asked questions
Can I take Carvedilol with Sevoflurane?
MediHelp rates the interaction as moderate. Carvedilol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane causes vasodilation and myocardial depression, and carvedilol adds beta-blockade and alpha-1 blockade. Together they can cause marked hypotension and bradycardia during anesthesia.
How serious is the interaction between Carvedilol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally continue beta-blockers perioperatively, and make the anesthesia team aware of carvedilol use. Monitor blood pressure and heart rate continuously and treat hypotension with fluids or vasopressors as needed.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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