Drug interactions
Caspofungin + Ceftobiprole medocaril
Severity: Minor
Caspofungin and Ceftobiprole medocaril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole may inhibit OATP1B1 and OATP1B3, which participate in hepatic uptake of caspofungin. Caspofungin levels could increase, but the clinical consequences are probably limited.
What this interaction means in plain words
Caspofungin and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1/1B3-mediated hepatic uptake of caspofungin.
What to do
No dose change is usually needed; monitor liver enzymes during prolonged combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Frequently asked questions
Can I take Caspofungin with Ceftobiprole medocaril?
MediHelp rates the interaction as minor. Caspofungin and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole may inhibit OATP1B1 and OATP1B3, which participate in hepatic uptake of caspofungin. Caspofungin levels could increase, but the clinical consequences are probably limited.
How serious is the interaction between Caspofungin and Ceftobiprole medocaril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor liver enzymes during prolonged combined therapy.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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