Drug interactions
Caspofungin + Cyclosporin
Severity: Moderate
Caspofungin and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine raises caspofungin exposure, and transient elevations of liver transaminases have been seen with the combination. Caspofungin does not materially change cyclosporine levels.
What this interaction means in plain words
Caspofungin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits OATP1B1-mediated hepatic uptake of caspofungin, raising its plasma concentrations.
What to do
Monitor liver enzymes during concurrent therapy and discontinue if clinically significant hepatotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporine Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Frequently asked questions
Can I take Caspofungin with Cyclosporin?
MediHelp rates the interaction as moderate. Caspofungin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine raises caspofungin exposure, and transient elevations of liver transaminases have been seen with the combination. Caspofungin does not materially change cyclosporine levels.
How serious is the interaction between Caspofungin and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes during concurrent therapy and discontinue if clinically significant hepatotoxicity develops.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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