Drug interactions
Carbamazepine + Caspofungin
Severity: Moderate
Carbamazepine and Caspofungin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine, an enzyme inducer, may lower caspofungin concentrations and reduce antifungal efficacy. Labeling suggests considering a higher caspofungin dose with inducers such as carbamazepine.
What this interaction means in plain words
Carbamazepine and Caspofungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Caspofungin belongs to Anti Fungals.
Why it happens
Induction of caspofungin clearance by carbamazepine.
What to do
Consider a caspofungin maintenance dose of 70 mg daily in adults when given with carbamazepine, and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Cyclosporine Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Caspofungin?
MediHelp rates the interaction as moderate. Carbamazepine and Caspofungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine, an enzyme inducer, may lower caspofungin concentrations and reduce antifungal efficacy. Labeling suggests considering a higher caspofungin dose with inducers such as carbamazepine.
How serious is the interaction between Carbamazepine and Caspofungin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a caspofungin maintenance dose of 70 mg daily in adults when given with carbamazepine, and monitor clinical response.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Cyclosporin, Cyclosporine. The full list is on the Caspofungin page.
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