Drug interactions
Caspofungin + Efavirenz
Severity: Moderate
Caspofungin and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower caspofungin exposure, which could reduce antifungal efficacy. Caspofungin labeling lists efavirenz among inducers for which a higher dose may be considered.
What this interaction means in plain words
Caspofungin and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Efavirenz belongs to Anti Virals.
Why it happens
Proposed induction of caspofungin clearance by efavirenz; the exact mechanism is not firmly established.
What to do
Consider increasing caspofungin to 70 mg daily in adults if the response is inadequate, and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Cyclosporine Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Fosphenytoin Moderate
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Caspofungin with Efavirenz?
MediHelp rates the interaction as moderate. Caspofungin and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower caspofungin exposure, which could reduce antifungal efficacy. Caspofungin labeling lists efavirenz among inducers for which a higher dose may be considered.
How serious is the interaction between Caspofungin and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider increasing caspofungin to 70 mg daily in adults if the response is inadequate, and monitor clinical response.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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