Drug interactions
Caspofungin + Ethotoin
Severity: Minor
Caspofungin and Ethotoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydantoin anticonvulsants may lower caspofungin exposure, as seen with phenytoin. Data for ethotoin specifically are lacking, so the effect is extrapolated and its significance is uncertain.
What this interaction means in plain words
Caspofungin and Ethotoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible enzyme induction by the hydantoin, extrapolated from phenytoin, increasing caspofungin clearance.
What to do
Watch for inadequate antifungal response. Consider a higher caspofungin maintenance dose per labeling for inducers if clinical response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Frequently asked questions
Can I take Caspofungin with Ethotoin?
MediHelp rates the interaction as minor. Caspofungin and Ethotoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydantoin anticonvulsants may lower caspofungin exposure, as seen with phenytoin. Data for ethotoin specifically are lacking, so the effect is extrapolated and its significance is uncertain.
How serious is the interaction between Caspofungin and Ethotoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for inadequate antifungal response. Consider a higher caspofungin maintenance dose per labeling for inducers if clinical response is poor.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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