Drug interactions
Caspofungin + Rifampin
Severity: Moderate
Caspofungin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin can alter caspofungin exposure, with a reduction in trough concentrations seen with continued dosing. This may reduce antifungal efficacy.
What this interaction means in plain words
Caspofungin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces hepatic enzymes and transporters involved in caspofungin disposition, lowering concentrations.
What to do
Use caspofungin 70 mg daily in adults when co-administered with rifampin, per labeling. Monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Frequently asked questions
Can I take Caspofungin with Rifampin?
MediHelp rates the interaction as moderate. Caspofungin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin can alter caspofungin exposure, with a reduction in trough concentrations seen with continued dosing. This may reduce antifungal efficacy.
How serious is the interaction between Caspofungin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use caspofungin 70 mg daily in adults when co-administered with rifampin, per labeling. Monitor clinical response.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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