Drug interactions
Caspofungin + Saccharomyces boulardii
Severity: Moderate
Caspofungin and Saccharomyces boulardii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saccharomyces boulardii is a live yeast, and systemic antifungals such as caspofungin can reduce its viability. This could lessen the probiotic effect. In addition, live yeast probiotics have caused fungemia in critically ill patients or those with central lines.
What this interaction means in plain words
Caspofungin and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: antifungal activity against the live yeast probiotic.
What to do
Avoid the probiotic during systemic antifungal therapy, particularly in immunocompromised or critically ill patients with central venous catheters. If wanted in other patients, resume after antifungal therapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Frequently asked questions
Can I take Caspofungin with Saccharomyces boulardii?
MediHelp rates the interaction as moderate. Caspofungin and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saccharomyces boulardii is a live yeast, and systemic antifungals such as caspofungin can reduce its viability. This could lessen the probiotic effect. In addition, live yeast probiotics have caused fungemia in critically ill patients or those with central lines.
How serious is the interaction between Caspofungin and Saccharomyces boulardii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the probiotic during systemic antifungal therapy, particularly in immunocompromised or critically ill patients with central venous catheters. If wanted in other patients, resume after antifungal therapy ends.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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