Drug interactions
Caspofungin + Sofosbuvir / velpatasvir
Severity: Minor
Caspofungin and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits OATP1B1/1B3 and may modestly increase caspofungin hepatic uptake-dependent exposure. The clinical consequence is likely small.
What this interaction means in plain words
Caspofungin and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Velpatasvir inhibition of OATP hepatic uptake transporters may raise caspofungin concentrations.
What to do
No dose adjustment is needed; monitor liver enzymes during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Frequently asked questions
Can I take Caspofungin with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Caspofungin and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits OATP1B1/1B3 and may modestly increase caspofungin hepatic uptake-dependent exposure. The clinical consequence is likely small.
How serious is the interaction between Caspofungin and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor liver enzymes during combined use.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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