Drug interactions
Cefaclor + Voclosporin
Severity: Minor
Cefaclor and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, is nephrotoxic. Cefaclor has little intrinsic nephrotoxicity, so any additive kidney risk is small, but renal function matters in lupus nephritis patients receiving voclosporin.
What this interaction means in plain words
Cefaclor and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefaclor belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Possible additive renal effects; cefaclor has minimal nephrotoxic potential, so the interaction is largely theoretical.
What to do
Monitor serum creatinine and eGFR as already required for voclosporin therapy. No cefaclor adjustment is needed unless renal function worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Cefaclor with Voclosporin?
MediHelp rates the interaction as minor. Cefaclor and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin, a calcineurin inhibitor, is nephrotoxic. Cefaclor has little intrinsic nephrotoxicity, so any additive kidney risk is small, but renal function matters in lupus nephritis patients receiving voclosporin.
How serious is the interaction between Cefaclor and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR as already required for voclosporin therapy. No cefaclor adjustment is needed unless renal function worsens.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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