Drug interactions
Cefadroxil + Mefenamic acid
Severity: Minor
Cefadroxil and Mefenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefadroxil is eliminated by renal tubular secretion and may compete with acidic drugs such as mefenamic acid. This could modestly raise mefenamic acid levels. A clinically meaningful effect has not been well documented.
What this interaction means in plain words
Cefadroxil and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Competition for renal tubular secretion through organic anion transporters.
What to do
No dose change is usually needed. Be aware of increased NSAID adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Mefenamic acid?
MediHelp rates the interaction as minor. Cefadroxil and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefadroxil is eliminated by renal tubular secretion and may compete with acidic drugs such as mefenamic acid. This could modestly raise mefenamic acid levels. A clinically meaningful effect has not been well documented.
How serious is the interaction between Cefadroxil and Mefenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Be aware of increased NSAID adverse effects in patients with renal impairment.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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