Drug interactions
Cefamandole + Hydrochlorothiazide-irbesartan
Severity: Minor
Cefamandole and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins and thiazides are both secreted by renal organic anion transporters, so competition might slightly raise hydrochlorothiazide levels. The clinical effect is expected to be small.
What this interaction means in plain words
Cefamandole and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anion secretion.
What to do
No routine action is needed; monitor blood pressure and electrolytes as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Cefamandole with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Cefamandole and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalosporins and thiazides are both secreted by renal organic anion transporters, so competition might slightly raise hydrochlorothiazide levels. The clinical effect is expected to be small.
How serious is the interaction between Cefamandole and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor blood pressure and electrolytes as usual.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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