Drug interactions
Cefazolin + Voclosporin
Severity: Moderate
Cefazolin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and cefazolin is occasionally associated with kidney injury. Using them together may modestly add to the risk of reduced renal function, which matters in lupus nephritis patients who already have compromised kidneys.
What this interaction means in plain words
Cefazolin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefazolin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxic potential through pharmacodynamic effects on the kidney.
What to do
Monitor serum creatinine and eGFR during combined use and adjust the cefazolin dose to renal function. Reduce or interrupt voclosporin per labeling if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefazolin
- Amikacin + Cefazolin Moderate
- Bcg vaccine live + Cefazolin Moderate
- Cefazolin + Cholera vaccine Moderate
- Cefazolin + Dexamethasone-tobramycin Moderate
- Cefazolin + Gentamicin Moderate
- Cefazolin + Kanamycin Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Cefazolin with Voclosporin?
MediHelp rates the interaction as moderate. Cefazolin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and cefazolin is occasionally associated with kidney injury. Using them together may modestly add to the risk of reduced renal function, which matters in lupus nephritis patients who already have compromised kidneys.
How serious is the interaction between Cefazolin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR during combined use and adjust the cefazolin dose to renal function. Reduce or interrupt voclosporin per labeling if renal function declines.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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