Drug interactions
Cefdinir + Erythromycin
Severity: Minor
Cefdinir and Erythromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic antibiotics are theorized to blunt the activity of bactericidal beta-lactams that need actively dividing bacteria. Clinical evidence of reduced cefdinir efficacy is limited.
What this interaction means in plain words
Cefdinir and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefdinir belongs to Anti Bacterial; Erythromycin belongs to Anti Bacterial.
Why it happens
Theoretical pharmacodynamic antagonism between a bacteriostatic macrolide and a bactericidal beta-lactam.
What to do
Combination is generally acceptable when clinically indicated, such as in atypical coverage for pneumonia; monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Cefdinir
- Aluminum hydroxide + Cefdinir Moderate
- Cefdinir + Cholera vaccine Moderate
- Cefdinir + Famotidine Moderate
- Cefdinir + Gentamicin Moderate
- Cefdinir + Microbiota Moderate
- Cefdinir + Nizatidine Moderate
Frequently asked questions
Can I take Cefdinir with Erythromycin?
MediHelp rates the interaction as minor. Cefdinir and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bacteriostatic antibiotics are theorized to blunt the activity of bactericidal beta-lactams that need actively dividing bacteria. Clinical evidence of reduced cefdinir efficacy is limited.
How serious is the interaction between Cefdinir and Erythromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Combination is generally acceptable when clinically indicated, such as in atypical coverage for pneumonia; monitor clinical response.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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