Drug interactions
Cefepime + Probenecid
Severity: Minor
Cefepime and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid may modestly reduce renal clearance of cefepime and raise its exposure. This matters mainly in renal impairment, where cefepime neurotoxicity is a concern.
What this interaction means in plain words
Cefepime and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefepime belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid competitively inhibits tubular secretion of cefepime, although cefepime is mainly cleared by filtration.
What to do
No action is usually needed; in renal impairment dose cefepime by creatinine clearance and watch for neurotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Cefepime
- Amikacin + Cefepime Moderate
- Cefepime + Cholera vaccine Moderate
- Cefepime + Dexamethasone-tobramycin Moderate
- Cefepime + Gentamicin Moderate
- Cefepime + Kanamycin Moderate
- Cefepime + Microbiota Moderate
Frequently asked questions
Can I take Cefepime with Probenecid?
MediHelp rates the interaction as minor. Cefepime and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid may modestly reduce renal clearance of cefepime and raise its exposure. This matters mainly in renal impairment, where cefepime neurotoxicity is a concern.
How serious is the interaction between Cefepime and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed; in renal impairment dose cefepime by creatinine clearance and watch for neurotoxicity.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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