Drug interactions
Cefixime + Neomycin
Severity: Minor
Cefixime and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so systemic aminoglycoside exposure is usually small. Cefixime is an oral cephalosporin with little nephrotoxic potential. A clinically meaningful additive kidney or ear injury is unlikely unless neomycin is absorbed.
What this interaction means in plain words
Cefixime and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefixime belongs to Anti Bacterial; Neomycin belongs to Anti Bacterial.
Why it happens
Theoretical additive nephrotoxicity and ototoxicity that requires systemic aminoglycoside absorption, which is minimal with oral neomycin.
What to do
No routine action is needed in patients with normal renal function and intact gut mucosa. Check renal function if neomycin is used long term or if the patient has renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Cefixime with Neomycin?
MediHelp rates the interaction as minor. Cefixime and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so systemic aminoglycoside exposure is usually small. Cefixime is an oral cephalosporin with little nephrotoxic potential. A clinically meaningful additive kidney or ear injury is unlikely unless neomycin is absorbed.
How serious is the interaction between Cefixime and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed in patients with normal renal function and intact gut mucosa. Check renal function if neomycin is used long term or if the patient has renal impairment.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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