Drug interactions
Cefixime + Voclosporin
Severity: Minor
Cefixime and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity. Cefixime is renally cleared and rarely associated with kidney injury, so any additive effect is small, though renal function may be affected in susceptible patients.
What this interaction means in plain words
Cefixime and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefixime belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Possible additive renal injury; cefixime has little intrinsic nephrotoxicity and no established pharmacokinetic interaction.
What to do
Monitor serum creatinine and eGFR as already required during voclosporin therapy, and adjust cefixime dose if creatinine clearance falls below the labeled threshold.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Cefixime with Voclosporin?
MediHelp rates the interaction as minor. Cefixime and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity. Cefixime is renally cleared and rarely associated with kidney injury, so any additive effect is small, though renal function may be affected in susceptible patients.
How serious is the interaction between Cefixime and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR as already required during voclosporin therapy, and adjust cefixime dose if creatinine clearance falls below the labeled threshold.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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