Drug interactions
Cefotetan + Meclofenamic acid
Severity: Minor
Cefotetan and Meclofenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are acidic compounds eliminated partly by renal tubular secretion, so meclofenamate exposure may rise slightly. Cefotetan can also cause hypoprothrombinemia and bleeding, which may add to the platelet-inhibiting and mucosal effects of the NSAID.
What this interaction means in plain words
Cefotetan and Meclofenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefotetan belongs to Anti Bacterial; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Competition for renal tubular anion secretion, plus additive bleeding tendency.
What to do
Monitor for bleeding signs and consider checking INR in at-risk patients such as the elderly, malnourished or renally impaired. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Cefotetan
- Cefotetan + Dronabinol Contraindicated
- Cefotetan + Warfarin Major
- Amikacin + Cefotetan Moderate
- Argatroban + Cefotetan Moderate
- Cefotetan + Dalteparin Moderate
- Cefotetan + Enoxaparin Moderate
Frequently asked questions
Can I take Cefotetan with Meclofenamic acid?
MediHelp rates the interaction as minor. Cefotetan and Meclofenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are acidic compounds eliminated partly by renal tubular secretion, so meclofenamate exposure may rise slightly. Cefotetan can also cause hypoprothrombinemia and bleeding, which may add to the platelet-inhibiting and mucosal effects of the NSAID.
How serious is the interaction between Cefotetan and Meclofenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and consider checking INR in at-risk patients such as the elderly, malnourished or renally impaired. No dose change is usually required.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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