Drug interactions
Cefoxitin + Probenecid
Severity: Minor
Cefoxitin and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid markedly decreases renal tubular secretion of cefoxitin, resulting in higher and longer-lasting concentrations. This is used intentionally in some regimens, such as for pelvic inflammatory disease.
What this interaction means in plain words
Cefoxitin and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefoxitin belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits OAT-mediated renal tubular secretion of cefoxitin.
What to do
No action is needed when combined intentionally; reduce cefoxitin dose in renal impairment as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Cefoxitin
- Amikacin + Cefoxitin Moderate
- Aztreonam + Cefoxitin Moderate
- Bcg vaccine live + Cefoxitin Moderate
- Cefoxitin + Chloramphenicol Moderate
- Cefoxitin + Cholera vaccine Moderate
- Cefoxitin + Dexamethasone-tobramycin Moderate
Frequently asked questions
Can I take Cefoxitin with Probenecid?
MediHelp rates the interaction as minor. Cefoxitin and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid markedly decreases renal tubular secretion of cefoxitin, resulting in higher and longer-lasting concentrations. This is used intentionally in some regimens, such as for pelvic inflammatory disease.
How serious is the interaction between Cefoxitin and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed when combined intentionally; reduce cefoxitin dose in renal impairment as usual.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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