Drug interactions
Cefoxitin + Voclosporin
Severity: Moderate
Cefoxitin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and cefoxitin has been associated with occasional renal impairment. Using both may add to the risk of reduced kidney function, particularly in patients with lupus nephritis who already have compromised renal function.
What this interaction means in plain words
Cefoxitin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefoxitin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity, with voclosporin causing afferent arteriolar vasoconstriction and cefoxitin having potential tubular toxicity.
What to do
Monitor serum creatinine and eGFR closely during and after the antibiotic course, and reduce the voclosporin dose per labeling if renal function declines. Adjust cefoxitin dosing to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefoxitin
- Amikacin + Cefoxitin Moderate
- Aztreonam + Cefoxitin Moderate
- Bcg vaccine live + Cefoxitin Moderate
- Cefoxitin + Chloramphenicol Moderate
- Cefoxitin + Cholera vaccine Moderate
- Cefoxitin + Dexamethasone-tobramycin Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Cefoxitin with Voclosporin?
MediHelp rates the interaction as moderate. Cefoxitin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and cefoxitin has been associated with occasional renal impairment. Using both may add to the risk of reduced kidney function, particularly in patients with lupus nephritis who already have compromised renal function.
How serious is the interaction between Cefoxitin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR closely during and after the antibiotic course, and reduce the voclosporin dose per labeling if renal function declines. Adjust cefoxitin dosing to renal function.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
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