Drug interactions
Cefpodoxime + Didanosine
Severity: Moderate
Cefpodoxime and Didanosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Didanosine chewable tablets and oral solution contain buffering agents that raise gastric pH, and cefpodoxime absorption depends on an acidic environment. Co-administration can lower cefpodoxime exposure and may reduce its efficacy.
What this interaction means in plain words
Cefpodoxime and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Didanosine belongs to Anti Virals.
Why it happens
Buffered didanosine formulations increase gastric pH, reducing dissolution and absorption of cefpodoxime proxetil.
What to do
Give cefpodoxime at least 2 hours before buffered didanosine formulations. Monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Hydroxyurea Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
Frequently asked questions
Can I take Cefpodoxime with Didanosine?
MediHelp rates the interaction as moderate. Cefpodoxime and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Didanosine chewable tablets and oral solution contain buffering agents that raise gastric pH, and cefpodoxime absorption depends on an acidic environment. Co-administration can lower cefpodoxime exposure and may reduce its efficacy.
How serious is the interaction between Cefpodoxime and Didanosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cefpodoxime at least 2 hours before buffered didanosine formulations. Monitor clinical response to the antibiotic.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Amikacin, Calcium carbonate. The full list is on the Cefpodoxime page.
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