Drug interactions
Cefpodoxime + Erythromycin
Severity: Minor
Cefpodoxime and Erythromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macrolide bacteriostatic activity could theoretically blunt the bactericidal effect of a beta-lactam that depends on actively dividing bacteria. Clinical evidence of reduced cure rates is limited and inconsistent.
What this interaction means in plain words
Cefpodoxime and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpodoxime belongs to Anti Bacterial; Erythromycin belongs to Anti Bacterial.
Why it happens
Theoretical pharmacodynamic antagonism between a protein synthesis inhibitor and a cell-wall-active bactericidal agent.
What to do
No routine change is needed; for atypical plus typical pathogen coverage such as pneumonia, the combination is commonly used and clinical response should be monitored.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Frequently asked questions
Can I take Cefpodoxime with Erythromycin?
MediHelp rates the interaction as minor. Cefpodoxime and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Macrolide bacteriostatic activity could theoretically blunt the bactericidal effect of a beta-lactam that depends on actively dividing bacteria. Clinical evidence of reduced cure rates is limited and inconsistent.
How serious is the interaction between Cefpodoxime and Erythromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; for atypical plus typical pathogen coverage such as pneumonia, the combination is commonly used and clinical response should be monitored.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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