Drug interactions
Cefpodoxime + Streptomycin
Severity: Minor
Cefpodoxime and Streptomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can affect the kidney, and aminoglycosides also damage the inner ear. Oral cefpodoxime has little nephrotoxic potential of its own, so any added renal risk is small, but renal impairment can raise streptomycin levels and its toxicity.
What this interaction means in plain words
Cefpodoxime and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpodoxime belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Possible additive renal effects; aminoglycoside nephrotoxicity and ototoxicity are concentration-dependent and worsen if renal clearance falls.
What to do
Monitor serum creatinine and streptomycin levels during therapy and ask about hearing or balance symptoms. Adjust the streptomycin dose to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Other interactions of Streptomycin
Frequently asked questions
Can I take Cefpodoxime with Streptomycin?
MediHelp rates the interaction as minor. Cefpodoxime and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can affect the kidney, and aminoglycosides also damage the inner ear. Oral cefpodoxime has little nephrotoxic potential of its own, so any added renal risk is small, but renal impairment can raise streptomycin levels and its toxicity.
How serious is the interaction between Cefpodoxime and Streptomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels during therapy and ask about hearing or balance symptoms. Adjust the streptomycin dose to renal function.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Amikacin, Calcium carbonate. The full list is on the Cefpodoxime page.
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