Drug interactions
Cefprozil + Enalapril-hydrochlorothiazide
Severity: Minor
Cefprozil and Enalapril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may reduce renal tubular secretion of cefprozil and raise its blood levels modestly. Cefprozil has a wide safety margin, so clinical consequences are usually small, though accumulation is more relevant in renal impairment.
What this interaction means in plain words
Cefprozil and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefprozil belongs to Anti Bacterial; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Competition for renal tubular organic anion secretion reduces cefprozil clearance.
What to do
No routine adjustment is needed. In patients with reduced renal function, review the cefprozil dose and monitor for adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Frequently asked questions
Can I take Cefprozil with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Cefprozil and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may reduce renal tubular secretion of cefprozil and raise its blood levels modestly. Cefprozil has a wide safety margin, so clinical consequences are usually small, though accumulation is more relevant in renal impairment.
How serious is the interaction between Cefprozil and Enalapril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. In patients with reduced renal function, review the cefprozil dose and monitor for adverse effects.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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