Drug interactions
Cefprozil + Hydrochlorothiazide-losartan
Severity: Minor
Cefprozil and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and cefprozil are eliminated partly by renal tubular secretion, so hydrochlorothiazide may modestly raise cefprozil levels. The effect is small and seldom clinically significant except in renal impairment.
What this interaction means in plain words
Cefprozil and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefprozil belongs to Anti Bacterial; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular secretion via organic anion transporters.
What to do
No dose change is normally needed. Consider renal function when dosing cefprozil in patients with impaired kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Frequently asked questions
Can I take Cefprozil with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Cefprozil and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both thiazides and cefprozil are eliminated partly by renal tubular secretion, so hydrochlorothiazide may modestly raise cefprozil levels. The effect is small and seldom clinically significant except in renal impairment.
How serious is the interaction between Cefprozil and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Consider renal function when dosing cefprozil in patients with impaired kidney function.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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