Drug interactions
Cefprozil + Probenecid
Severity: Minor
Cefprozil and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid slows the renal elimination of cefprozil, producing higher and more prolonged serum concentrations. Cephalosporins have a wide therapeutic index, so the increase is seldom clinically important.
What this interaction means in plain words
Cefprozil and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefprozil belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid blocks renal tubular anion secretion of cefprozil.
What to do
No dose adjustment is usually required. Monitor for adverse effects in patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Frequently asked questions
Can I take Cefprozil with Probenecid?
MediHelp rates the interaction as minor. Cefprozil and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid slows the renal elimination of cefprozil, producing higher and more prolonged serum concentrations. Cephalosporins have a wide therapeutic index, so the increase is seldom clinically important.
How serious is the interaction between Cefprozil and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor for adverse effects in patients with reduced renal function.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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