Drug interactions
Cefprozil + Warfarin
Severity: Moderate
Cefprozil and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins have been associated with raised INR and bleeding in some patients on warfarin, although reports are inconsistent. Infection and poor oral intake can also alter anticoagulant response.
What this interaction means in plain words
Cefprozil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefprozil belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
Possibly reduced vitamin K-producing gut flora; the mechanism is not firmly established.
What to do
Check INR within a few days of starting cefprozil and after completion. Reduce the warfarin dose if the INR rises, and counsel the patient about bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Cefprozil with Warfarin?
MediHelp rates the interaction as moderate. Cefprozil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins have been associated with raised INR and bleeding in some patients on warfarin, although reports are inconsistent. Infection and poor oral intake can also alter anticoagulant response.
How serious is the interaction between Cefprozil and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a few days of starting cefprozil and after completion. Reduce the warfarin dose if the INR rises, and counsel the patient about bleeding signs.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
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