Drug interactions
Ceftaroline fosamil + Neomycin po
Severity: Minor
Ceftaroline fosamil and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed from intact gut, so systemic exposure is typically low. Absorption may increase with bowel inflammation or renal impairment, making additive kidney or ear toxicity with ceftaroline conceivable.
What this interaction means in plain words
Ceftaroline fosamil and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive nephrotoxicity if systemic neomycin absorption occurs.
What to do
Monitor renal function in patients with renal impairment, bowel inflammation, or prolonged neomycin use, and adjust ceftaroline dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ceftaroline fosamil
- Amikacin + Ceftaroline fosamil Moderate
- Ceftaroline fosamil + Cholera vaccine Moderate
- Ceftaroline fosamil + Gentamicin Moderate
- Ceftaroline fosamil + Kanamycin Moderate
- Ceftaroline fosamil + Microbiota Moderate
- Ceftaroline fosamil + Plazomicin Moderate
Frequently asked questions
Can I take Ceftaroline fosamil with Neomycin po?
MediHelp rates the interaction as minor. Ceftaroline fosamil and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed from intact gut, so systemic exposure is typically low. Absorption may increase with bowel inflammation or renal impairment, making additive kidney or ear toxicity with ceftaroline conceivable.
How serious is the interaction between Ceftaroline fosamil and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in patients with renal impairment, bowel inflammation, or prolonged neomycin use, and adjust ceftaroline dose to creatinine clearance.
What other medicines interact with Ceftaroline fosamil?
MediHelp also lists interactions of Ceftaroline fosamil with, for example, Amikacin, Cholera vaccine, Gentamicin. The full list is on the Ceftaroline fosamil page.
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