Drug interactions
Ceftaroline fosamil + Typhoid vaccine live
Severity: Moderate
Ceftaroline fosamil and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi colonizing the gut. Ceftaroline has broad gram-negative activity against Enterobacterales and might reduce vaccine viability, though its activity against Salmonella is not well characterized.
What this interaction means in plain words
Ceftaroline fosamil and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may inhibit the live attenuated Salmonella strain, reducing immunogenicity.
What to do
Give live oral typhoid vaccine at least 3 days after the last ceftaroline dose, or vaccinate before starting it. The inactivated Vi vaccine is an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftaroline fosamil
- Amikacin + Ceftaroline fosamil Moderate
- Ceftaroline fosamil + Cholera vaccine Moderate
- Ceftaroline fosamil + Gentamicin Moderate
- Ceftaroline fosamil + Kanamycin Moderate
- Ceftaroline fosamil + Microbiota Moderate
- Ceftaroline fosamil + Plazomicin Moderate
Frequently asked questions
Can I take Ceftaroline fosamil with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Ceftaroline fosamil and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi colonizing the gut. Ceftaroline has broad gram-negative activity against Enterobacterales and might reduce vaccine viability, though its activity against Salmonella is not well characterized.
How serious is the interaction between Ceftaroline fosamil and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the last ceftaroline dose, or vaccinate before starting it. The inactivated Vi vaccine is an alternative.
What other medicines interact with Ceftaroline fosamil?
MediHelp also lists interactions of Ceftaroline fosamil with, for example, Amikacin, Cholera vaccine, Gentamicin. The full list is on the Ceftaroline fosamil page.
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