Drug interactions
Ceftobiprole medocaril + Digoxin
Severity: Minor
Ceftobiprole medocaril and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3, but digoxin is not a recognized substrate of these transporters. A clinically important change in digoxin exposure is not established.
What this interaction means in plain words
Ceftobiprole medocaril and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical OATP inhibition by ceftobiprole; the relevance to digoxin disposition is unproven.
What to do
No routine action is needed beyond awareness. Monitor digoxin levels if signs of toxicity appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Ceftobiprole medocaril with Digoxin?
MediHelp rates the interaction as minor. Ceftobiprole medocaril and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits OATP1B1 and OATP1B3, but digoxin is not a recognized substrate of these transporters. A clinically important change in digoxin exposure is not established.
How serious is the interaction between Ceftobiprole medocaril and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed beyond awareness. Monitor digoxin levels if signs of toxicity appear.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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