Drug interactions
Ceftobiprole medocaril + Fexofenadine
Severity: Minor
Ceftobiprole medocaril and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits the hepatic uptake transporters OATP1B1 and OATP1B3, which contribute to fexofenadine disposition. Fexofenadine exposure may rise, though it has a wide safety margin.
What this interaction means in plain words
Ceftobiprole medocaril and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
OATP1B1/1B3 inhibition by ceftobiprole reduces fexofenadine uptake and clearance.
What to do
No dose change is usually required. Monitor for increased antihistamine adverse effects during the antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceftobiprole medocaril and Fexofenadine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Ceftobiprole medocaril with Fexofenadine?
MediHelp rates the interaction as minor. Ceftobiprole medocaril and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits the hepatic uptake transporters OATP1B1 and OATP1B3, which contribute to fexofenadine disposition. Fexofenadine exposure may rise, though it has a wide safety margin.
How serious is the interaction between Ceftobiprole medocaril and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor for increased antihistamine adverse effects during the antibiotic course.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
