Drug interactions
Ceftobiprole medocaril + Pravastatin
Severity: Minor
Ceftobiprole medocaril and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro, which may modestly increase exposure to pravastatin, an OATP substrate. Ceftobiprole is given for short courses, so the clinical effect is probably limited.
What this interaction means in plain words
Ceftobiprole medocaril and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake reduces pravastatin hepatic clearance.
What to do
Usually no change is required; monitor for muscle symptoms during the antibiotic course or briefly hold pravastatin in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Frequently asked questions
Can I take Ceftobiprole medocaril with Pravastatin?
MediHelp rates the interaction as minor. Ceftobiprole medocaril and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro, which may modestly increase exposure to pravastatin, an OATP substrate. Ceftobiprole is given for short courses, so the clinical effect is probably limited.
How serious is the interaction between Ceftobiprole medocaril and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is required; monitor for muscle symptoms during the antibiotic course or briefly hold pravastatin in high-risk patients.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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