Drug interactions
Ceftriaxone + Dalteparin
Severity: Minor
Ceftriaxone and Dalteparin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No clinically meaningful interaction between ceftriaxone and dalteparin is established. Ceftriaxone rarely causes coagulopathy, mainly in debilitated patients with poor vitamin K intake. Any additive bleeding risk is small.
What this interaction means in plain words
Ceftriaxone and Dalteparin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceftriaxone belongs to Anti Bacterial; Dalteparin belongs to Cardiovascular.
Why it happens
Possible vitamin K depletion by ceftriaxone adds theoretically to anticoagulant bleeding risk; no direct effect on dalteparin.
What to do
No dose change is needed; monitor for bleeding and consider anti-Xa testing in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Ceftriaxone with Dalteparin?
MediHelp rates the interaction as minor. Ceftriaxone and Dalteparin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No clinically meaningful interaction between ceftriaxone and dalteparin is established. Ceftriaxone rarely causes coagulopathy, mainly in debilitated patients with poor vitamin K intake. Any additive bleeding risk is small.
How serious is the interaction between Ceftriaxone and Dalteparin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for bleeding and consider anti-Xa testing in renal impairment.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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