Drug interactions
Cefuroxime + Omeprazole
Severity: Moderate
Cefuroxime and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Absorption of cefuroxime axetil is reduced when gastric acidity is lowered, which may reduce antibiotic exposure. Food partly offsets this.
What this interaction means in plain words
Cefuroxime and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefuroxime belongs to Anti Bacterial; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces cefuroxime axetil absorption.
What to do
Give cefuroxime axetil with food, and consider an alternative antibiotic if the infection is serious and the PPI cannot be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Frequently asked questions
Can I take Cefuroxime with Omeprazole?
MediHelp rates the interaction as moderate. Cefuroxime and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Absorption of cefuroxime axetil is reduced when gastric acidity is lowered, which may reduce antibiotic exposure. Food partly offsets this.
How serious is the interaction between Cefuroxime and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cefuroxime axetil with food, and consider an alternative antibiotic if the infection is serious and the PPI cannot be stopped.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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