Drug interactions
Celecoxib + Ciprofloxacin
Severity: Moderate
Celecoxib and Ciprofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the seizure-provoking potential of fluoroquinolones. The risk is low overall but relevant in patients with epilepsy, renal impairment or high doses.
What this interaction means in plain words
Celecoxib and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors may be potentiated by NSAIDs; the exact mechanism is not firmly established.
What to do
Avoid the combination in patients with a seizure history or lowered seizure threshold. Use renally adjusted ciprofloxacin doses and counsel patients to report neurological symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Celecoxib with Ciprofloxacin?
MediHelp rates the interaction as moderate. Celecoxib and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the seizure-provoking potential of fluoroquinolones. The risk is low overall but relevant in patients with epilepsy, renal impairment or high doses.
How serious is the interaction between Celecoxib and Ciprofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history or lowered seizure threshold. Use renally adjusted ciprofloxacin doses and counsel patients to report neurological symptoms.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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