Drug interactions
Celecoxib + Clopidogrel
Severity: Moderate
Celecoxib and Clopidogrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with clopidogrel increases the risk of gastrointestinal and other bleeding. Celecoxib has less platelet effect than non-selective NSAIDs but still adds mucosal risk.
What this interaction means in plain words
Celecoxib and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Clopidogrel belongs to Cardiovascular.
Why it happens
Additive impairment of hemostasis from P2Y12 inhibition plus NSAID effects on platelets and gastric mucosal integrity.
What to do
Use only if clearly needed, and consider gastroprotection with a proton pump inhibitor that does not inhibit CYP2C19 strongly, such as pantoprazole. Monitor for bleeding and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Celecoxib with Clopidogrel?
MediHelp rates the interaction as moderate. Celecoxib and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with clopidogrel increases the risk of gastrointestinal and other bleeding. Celecoxib has less platelet effect than non-selective NSAIDs but still adds mucosal risk.
How serious is the interaction between Celecoxib and Clopidogrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if clearly needed, and consider gastroprotection with a proton pump inhibitor that does not inhibit CYP2C19 strongly, such as pantoprazole. Monitor for bleeding and anemia.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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