Drug interactions
Celecoxib + Desipramine
Severity: Moderate
Celecoxib and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a moderate inhibitor of CYP2D6 and can raise desipramine plasma concentrations, since desipramine is cleared mainly through this enzyme. Higher exposure may increase anticholinergic effects, sedation, and cardiac conduction effects.
What this interaction means in plain words
Celecoxib and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Desipramine belongs to Central Nervous System.
Why it happens
Celecoxib inhibits CYP2D6-mediated hydroxylation of desipramine, reducing its clearance.
What to do
Monitor for tricyclic adverse effects and consider an ECG or plasma level measurement if symptoms arise. Reduce the desipramine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Celecoxib with Desipramine?
MediHelp rates the interaction as moderate. Celecoxib and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib is a moderate inhibitor of CYP2D6 and can raise desipramine plasma concentrations, since desipramine is cleared mainly through this enzyme. Higher exposure may increase anticholinergic effects, sedation, and cardiac conduction effects.
How serious is the interaction between Celecoxib and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider an ECG or plasma level measurement if symptoms arise. Reduce the desipramine dose if toxicity appears.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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