Drug interactions
Celecoxib + Dextromethorphan
Severity: Minor
Celecoxib and Dextromethorphan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a weak CYP2D6 inhibitor and may slightly increase dextromethorphan exposure. The clinical effect is generally small.
What this interaction means in plain words
Celecoxib and Dextromethorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Dextromethorphan belongs to Respiratory.
Why it happens
Weak inhibition of CYP2D6 by celecoxib reduces dextromethorphan metabolism.
What to do
No routine adjustment is needed; advise patients to report excess drowsiness or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Dextromethorphan?
MediHelp rates the interaction as minor. Celecoxib and Dextromethorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib is a weak CYP2D6 inhibitor and may slightly increase dextromethorphan exposure. The clinical effect is generally small.
How serious is the interaction between Celecoxib and Dextromethorphan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; advise patients to report excess drowsiness or dizziness.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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