Drug interactions
Celecoxib + Diclofenac
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Concomitant use of two NSAIDs increases risk of serious GI bleeding/ulceration, acute kidney injury, fluid retention/hypertension, and cardiovascular events without added analgesic benefit.
Mechanism of action
Additive inhibition of COX-1/COX-2 → reduced protective prostaglandins in GI tract and kidneys; cumulative NSAID adverse effect profile.
Clinical management
Avoid combined use. If unavoidable, use lowest effective doses for the shortest duration; consider PPI gastroprotection if GI risk; monitor for GI bleeding, SCr/BUN, urine output, BP, edema; counsel on warning signs.
Drug reference
References
- Celecoxib (CELEBREX) Prescribing Information — FDA Label
- Diclofenac Sodium Prescribing Information (e.g., Voltaren) — FDA Label
- Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Drug Interactions — Lexicomp
Frequently asked questions
Can I take Celecoxib with Diclofenac?
The interaction is rated: Major. Concomitant use of two NSAIDs increases risk of serious GI bleeding/ulceration, acute kidney injury, fluid retention/hypertension, and cardiovascular events without added analgesic benefit.
How serious is the interaction between Celecoxib and Diclofenac?
The interaction is rated: Major. Evidence level: High.
How is the interaction between Celecoxib and Diclofenac managed?
Avoid combined use. If unavoidable, use lowest effective doses for the shortest duration; consider PPI gastroprotection if GI risk; monitor for GI bleeding, SCr/BUN, urine output, BP, edema; counsel on warning signs.
Why do Celecoxib and Diclofenac interact?
Additive inhibition of COX-1/COX-2 → reduced protective prostaglandins in GI tract and kidneys; cumulative NSAID adverse effect profile.
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