Drug interactions
Celecoxib + Diflunisal
Severity: Moderate
Celecoxib and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds gastrointestinal, renal and cardiovascular toxicity without a proven gain in pain relief. Bleeding risk and the chance of renal impairment and hyperkalemia are higher than with either drug alone.
What this interaction means in plain words
Celecoxib and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Diflunisal belongs to Musculoskeletal.
Why it happens
Additive inhibition of cyclooxygenase and prostaglandin synthesis, affecting platelets, gastric mucosa and renal perfusion.
What to do
Avoid concurrent use of two NSAIDs and keep to a single agent at the lowest effective dose. If the combination cannot be avoided, monitor renal function, potassium and for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Diflunisal?
MediHelp rates the interaction as moderate. Celecoxib and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two NSAIDs adds gastrointestinal, renal and cardiovascular toxicity without a proven gain in pain relief. Bleeding risk and the chance of renal impairment and hyperkalemia are higher than with either drug alone.
How serious is the interaction between Celecoxib and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs and keep to a single agent at the lowest effective dose. If the combination cannot be avoided, monitor renal function, potassium and for GI bleeding.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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