Drug interactions
Celecoxib + Doxepin
Severity: Moderate
Celecoxib and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a weak to moderate CYP2D6 inhibitor and may raise doxepin concentrations. This can increase anticholinergic, sedative and cardiac effects, especially in poor CYP2D6 metabolizers or at higher doses.
What this interaction means in plain words
Celecoxib and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Doxepin belongs to Dermatology.
Why it happens
Celecoxib inhibits CYP2D6, reducing metabolism of doxepin.
What to do
Monitor for sedation, anticholinergic effects, and arrhythmia, and reduce the doxepin dose if adverse effects appear. Consider ECG monitoring in patients with cardiac risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Celecoxib with Doxepin?
MediHelp rates the interaction as moderate. Celecoxib and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib is a weak to moderate CYP2D6 inhibitor and may raise doxepin concentrations. This can increase anticholinergic, sedative and cardiac effects, especially in poor CYP2D6 metabolizers or at higher doses.
How serious is the interaction between Celecoxib and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects, and arrhythmia, and reduce the doxepin dose if adverse effects appear. Consider ECG monitoring in patients with cardiac risk.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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