Drug interactions
Celecoxib + Eltrombopag
Severity: Minor
Celecoxib and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes and some transporters in vitro, but celecoxib is mainly cleared by CYP2C9, so a relevant effect on celecoxib exposure is unlikely. The significance of this interaction is unclear.
What this interaction means in plain words
Celecoxib and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Eltrombopag belongs to Miscellaneous.
Why it happens
In vitro UGT inhibition by eltrombopag; celecoxib's primary pathway is CYP2C9 so the mechanism is not clearly established.
What to do
No routine adjustment is needed; be aware that NSAIDs raise bleeding concerns in patients with low platelet counts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Celecoxib with Eltrombopag?
MediHelp rates the interaction as minor. Celecoxib and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes and some transporters in vitro, but celecoxib is mainly cleared by CYP2C9, so a relevant effect on celecoxib exposure is unlikely. The significance of this interaction is unclear.
How serious is the interaction between Celecoxib and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be aware that NSAIDs raise bleeding concerns in patients with low platelet counts.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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