Drug interactions
Celecoxib + Etodolac
Severity: Major
Celecoxib and Etodolac: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are NSAIDs and taking them together offers no added benefit while adding to the risk of gastrointestinal bleeding, renal injury and cardiovascular events.
What this interaction means in plain words
Celecoxib and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Etodolac belongs to Musculoskeletal.
Why it happens
Duplicate cyclooxygenase inhibition produces additive adverse effects on the gastric mucosa, kidneys and cardiovascular system.
What to do
Avoid concurrent use of two NSAIDs and choose a single agent at the lowest effective dose. If pain control is inadequate, add a non-NSAID analgesic such as paracetamol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Etodolac?
MediHelp rates the interaction as major. Celecoxib and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are NSAIDs and taking them together offers no added benefit while adding to the risk of gastrointestinal bleeding, renal injury and cardiovascular events.
How serious is the interaction between Celecoxib and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs and choose a single agent at the lowest effective dose. If pain control is inadequate, add a non-NSAID analgesic such as paracetamol.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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