Drug interactions
Celecoxib + Flecainide
Severity: Moderate
Celecoxib and Flecainide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flecainide is partly metabolized by CYP2D6, and celecoxib is a moderate CYP2D6 inhibitor, so flecainide levels may rise. Because flecainide has a narrow therapeutic index with proarrhythmic potential, even modest increases may matter.
What this interaction means in plain words
Celecoxib and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Flecainide belongs to Cardiovascular.
Why it happens
Celecoxib inhibits CYP2D6, reducing flecainide metabolism.
What to do
Monitor ECG for QRS widening and PR prolongation and check flecainide plasma levels if available. Reduce the flecainide dose if conduction changes occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Celecoxib with Flecainide?
MediHelp rates the interaction as moderate. Celecoxib and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flecainide is partly metabolized by CYP2D6, and celecoxib is a moderate CYP2D6 inhibitor, so flecainide levels may rise. Because flecainide has a narrow therapeutic index with proarrhythmic potential, even modest increases may matter.
How serious is the interaction between Celecoxib and Flecainide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for QRS widening and PR prolongation and check flecainide plasma levels if available. Reduce the flecainide dose if conduction changes occur.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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